Spravato (esketamine)

At Montana Psychiatry, we know how exhausting it can be to struggle with treatment-resistant depression when standard medications haven’t provided the relief you need. It’s hard to stay hopeful when your symptoms persist despite your best efforts. That’s why we offer Spravato (esketamine) in Billings and Bozeman—an FDA-approved nasal spray specifically designed for adults who have not found success with traditional antidepressants.

We don’t believe in one-size-fits-all solutions, especially when it comes to complex depression. As a certified Spravato treatment center, we provide a structured, medically supervised environment where you can receive this breakthrough therapy safely. Our team monitors your progress during every session, adjusting your personalized plan to help you bridge the gap between “getting by” and truly feeling like yourself again.

Spravato

SPRAVATO® Therapy can help you:

  • Relieve treatment-resistant depression symptoms
  • Provide rapid relief – often within 24 hours
    Target depression through a different brain pathway than traditional antidepressants
  • Reduce suicidal thoughts in adults with major depressive disorder
  • Offer hope when other treatments haven’t worked

If you’re looking for a non-invasive treatment option and traditional antidepressants haven’t provided relief, our specialists can determine if SPRAVATO® is the right fit for you.

What is SPRAVATO® Therapy?

SPRAVATO® (esketamine) is an FDA-approved nasal spray specifically designed for adults with treatment-resistant depression. It’s a safe, clinically proven, and effective treatment conveniently provided in an outpatient setting under medical supervision. SPRAVATO® offers a medication-alternative approach that works differently than traditional antidepressants, targeting a different pathway in the brain for patients who have not found relief from standard medications.

How does SPRAVATO® work?

SPRAVATO® delivers treatment through a nasal spray containing esketamine, which targets a different pathway in the brain than traditional antidepressants. While most antidepressants work on serotonin, SPRAVATO® acts on the glutamate system in the brain, specifically the NMDA receptors, which play a key role in mood regulation. This innovative treatment targets the brain’s neural pathways by helping to restore connections between nerve cells, promoting increased activity in regions associated with mood regulation.

Unlike traditional treatments, such as medication, SPRAVATO® therapy can work rapidly and is administered under medical supervision. Many people report substantial improvements in mood, energy levels, and overall well-being, with some patients experiencing relief in as little as 24 hours. Throughout several sessions, typically conducted over a few weeks, SPRAVATO® therapy gradually helps restore brain function and alleviate depressive symptoms.

What can I expect?

For optimal results, SPRAVATO® requires a series of treatment sessions administered under medical supervision in our office. Typically, patients receive two treatments per week for the first four weeks. Prior to treatment, our medical experts will examine you and determine the appropriate dose for you. Each treatment session usually lasts around 2 to 2.5 hours, which includes the administration time and the required monitoring period afterward.

During each session, you’ll self-administer the nasal spray under our team’s guidance, and then you’ll be monitored for at least two hours to ensure your safety and comfort. Because SPRAVATO® can cause temporary side effects like dizziness or sedation, you’ll need to arrange transportation to and from each appointment – you cannot drive yourself home after treatment.

SPRAVATO® Patient Videos

What are the results like for SPRAVATO®?

Every patient’s body chemistry is different; results will differ from person to person. SPRAVATO® may be able to alleviate your symptoms of depression or help them disappear entirely. Some patients notice improvements in mood and depressive symptoms within 24 hours, while for others it may take several weeks of treatment sessions to experience the full benefits.

SPRAVATO® may work better for you if you:

  • Have tried at least two different antidepressants and haven’t found adequate relief
  • Are experiencing major depressive disorder with suicidal thoughts or behaviors
  • Have not experienced detachment from reality from your mental illness
  • Are looking for a treatment that works differently than traditional antidepressants
  • Can commit to the treatment schedule and supervision requirements

What We Treat

Depression

We help people living with major depression and similar conditions by pairing carefully chosen medications with ongoing support. The right antidepressants can ease persistent low moods, give you back energy, and make it easier to take part in daily life again.

Anxiety Disorders

Generalized anxiety disorder, panic disorder, and social anxiety can make everyday life feel overwhelming. Medications can help regulate stress responses and reduce persistent worry, giving you space to practice coping strategies with more ease.

Bipolar Disorders

For people living with bipolar disorder, we often use mood stabilizers and other medications to help even out the extreme highs and lows. People tell us they have more energy, sleep more soundly, and connect with others more easily, which makes everyday life feel a little easier to handle.

Insomnia

Sleep is essential for mental health. Our psychiatrists can recommend medications that support restful sleep while monitoring for side effects, helping you wake up feeling more refreshed and ready to take on the day.

PTSD

Post-traumatic stress disorder can affect mood, sleep, and focus. Medication management can help reduce intrusive thoughts, anxiety, and hyperarousal, allowing therapy and coping strategies to work more effectively.

ADHD

For people with attention-deficit/hyperactivity disorder, the right medications can help with focus and managing impulses. These changes make day-to-day tasks at work, school, or home feel more manageable and less stressful.

OCD

Obsessive-compulsive disorder can feel overwhelming, but medications can reduce intrusive thoughts and repetitive behaviors, giving you the mental space to apply behavioral strategies and live more freely.

Book An Appointment Today

If traditional treatment approaches haven’t improved your depression, TMS is a treatment option to consider. If you or someone you know is struggling with a depressive disorder, Montana Psychiatry and Brain Health Center offers TMS as an integrative, cutting-edge approach that can improve depression and quality of life. Contact us today to schedule a consultation appointment and determine if TMS may be the correct procedure for you.

Specialized Programs. Individualized Treatment.

From medication management to FDA-approved treatments for treatment-resistant depression, we offer comprehensive psychiatric services for adults and adolescents across Montana. Every care plan is individually designed to treat the whole person—not just a diagnosis.

Medication Management

Find your balance with expert psychiatric medication management. Our mental health specialists provide personalized treatment plans for ADHD, anxiety, and depression. We focus on evidence-based care and regular monitoring to ensure your wellness journey aligns with your lifestyle.

Spravato

Discover a new path for treatment-resistant depression. We offer FDA-approved esketamine nasal spray for those who haven’t found success with traditional antidepressants, providing rapid-acting support and in-office monitoring in a safe, professional setting.

Transcranial Magnetic Stimulation (TMS)​

Non-invasive relief for treatment-resistant depression. FDA-approved TMS uses magnetic pulses to stimulate mood centers without medication side effects. Reclaim your mental health with this drug-free, no-downtime treatment.

Ketamine Therapy

Experience rapid relief for depression and PTSD. Our clinical ketamine infusions target neural pathways to provide breakthroughs where traditional meds fail. Start your journey to healing in a safe, medically supervised environment.

Telemedicine Instructions

Skip the commute with secure virtual care. Our HIPAA-compliant telehealth platform offers insurance-friendly psychiatry and therapy sessions from home. Professional mental health support is now convenient, private, and just a click away.

What People Are Saying About Us

Amanda
Everyone at MT Psychiatry has been amazing to work with. Everyone is friendly and welcoming. They provide support in so many ways to make sure all bases are covered when it comes to mental health. It's been amazing to have providers listen without being dismissive or pushy. Highly recommend their services.
Katy
Montana Psychiatry is amazing to work with! They have helped me work through my mental health problems and I have been able to enjoy life again with their help! I highly recommend them, I dont know where I would be today without their gentle guidance, judgment free atmosphere, and caring team. Thank you for all that you do!
Joel
I cannot say one bad thing about this place. Everyone is extremely nice and helpful. I would recommend them to anyone struggling with mental health issues. All of the staff actually care about you. If you are looking for a sign to seek help this is it. There are brighter days ahead. Get help, this is the place.
Kelly
I like my counselor very much! She listens to me and helps guide me in the right direction! Also, when I'm not feeling good about myself; she does a good job of helping me feel better about myself! Thanks for everything!
Kimberly
Wow! I have been going to this clinic for TMS and Ketamine treatments since August 2025. The office staff, PAs, and doctors are so kind, caring, and helpful. If you need extra support, they even have an assistance line you can call when you need to talk. They have so much insight into mental health.